Pamphlet
HUGO-GT™ Next-Generation Humanized Models
This pamphlet introduces the HUGO-GT™ platform for next-generation humanized mouse models, enabling in situ replacement of mouse genes with full-length human orthologs for higher fidelity in disease modeling.
Overview
HUGO-GT™ is a next-generation humanized model platform developed by Cyagen. It replaces mouse genes with human orthologs at the native locus, preserving key genomic elements such as exons, introns, UTRs, and regulatory sequences. Compared to conventional knock-in or cDNA-based models, HUGO-GT™ ensures more accurate expression, splicing, and regulation—ideal for studying disease mechanisms and evaluating drug efficacy in preclinical research.
Key Insights
Build more predictive disease models with in situ gene replacement technology.
- Introduction to the HUGO-GT™ gene replacement strategy
- Comparison with traditional cDNA and knock-in models
- Application examples in SMA and HBB (β-thalassemia)
- Advantages of preserving human gene structure and regulation
- Suitable for neurological, hematological, and rare disease research
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