Poster
Human Genomic Ortholog (HUGO) Mouse Models as Tools for Understanding Pathophysiology and Therapeutics
This poster highlights Cyagen’s Human Genomic Ortholog (HUGO) mouse models, which enable detailed studies of human-specific biological processes and disease mechanisms. These models, including fully humanized genes such as hMAPT (with or without P301L/P301S mutations) and hMECP2-T158M, faithfully recapitulate key features of neurological disorders like Alzheimer’s disease, frontotemporal lobar degeneration, and Rett syndrome.
Overview
Humanized mouse models, or Human Genomic Ortholog (HUGO) models, provide a powerful platform to study human-specific biological processes and disease mechanisms in vivo. Cyagen has developed an extensive series of HUGO mouse models targeting neurological disorders, including mice with full replacement of mMapt by hMAPT (with P301L or P301S mutations) and hMECP2-T158M mice modeling Rett syndrome. These models faithfully recapitulate human disease phenotypes, such as cognitive impairment, motor deficits, and progressive neuropathology, enabling mechanistic studies and preclinical evaluation of therapeutic strategies. By bridging the gap between preclinical research and clinical relevance, these models are invaluable tools for investigating complex genetic, cellular, and synaptic interactions underlying human neurological diseases.
Key Insights
Advancing Neurological Research:
- Humanized Mouse Models for Neurological Research: Cyagen’s HUGO mouse models carry human genes (e.g., hMAPT, hMECP2) to faithfully replicate human neurological disease phenotypes.
- Disease-Relevant Phenotypes: Models exhibit clinically relevant features such as cognitive impairment, motor deficits, and progressive neuropathology, reflecting conditions like Alzheimer’s disease, frontotemporal lobar degeneration, and Rett syndrome.
- Translational Value: These models provide a robust platform for studying disease mechanisms, evaluating therapeutic strategies, and bridging preclinical research with clinical relevance.
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