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Animal Models
C57BL/6JCya-Svbpem1/Cya
Svbp is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Svbp knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Parvbem1flox/Cya
Parvb is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Parvb conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Parvbem1/Cya
Parvb is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Parvb knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Vbp1em1flox/Cya
Vbp1 is located on chromosome X of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Vbp1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Vbp1em1/Cya
Vbp1 is located on chromosome X of mice. Nuclease Technology will be used to design sgRNA; Vbp1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Ruvbl2em1flox/Cya
Ruvbl2 is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ruvbl2 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Ilvblem1flox/Cya
Ilvbl is located on chromosome 10 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Ilvbl conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Ilvblem1/Cya
Ilvbl is located on chromosome 10 of mice. Nuclease Technology will be used to design sgRNA; Ilvbl knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Mvb12aem1flox/Cya
Mvb12a is located on chromosome 8 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Mvb12a conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Pitpnaem1flox/Cya
Pitpna is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Pitpna conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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