C57BL/6JCya-Bpifa3em1flox/Cya
Common Name
Bpifa3-flox
Product ID
S-CKO-15685
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-73388-Bpifa3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Bpifa3-flox Mouse (Catalog S-CKO-15685) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Bpifa3-flox
Strain ID
CKOCMP-73388-Bpifa3-B6J-VA
Gene Name
Product ID
S-CKO-15685
Gene Alias
Splunc3, 1700058C13Rik
Background
C57BL/6JCya
Gene Full Name
BPI fold containing family A, member 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 2 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000028984
NCBI Transcript ID
NM_028528
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Bpifa3, with no common aliases mentioned in the provided references, has been associated with certain biological processes.
In the context of otitis media susceptibility in childhood, the BPIFA gene cluster on chromosome 20q11.21, where Bpifa3 is located, was identified as a top hit in a gene-based analysis in VEGAS (P(Gene) = 2 × 10(-5)) [2]. Also, in skin ageing, it was found to have an odds ratio of 1.859 (95% confidence interval [1.567, 2.151]), indicating its potential role in the genetic determinants of skin ageing [1].
Although no KO/CKO mouse models' findings are presented in the references, the gene-based analysis in the otitis media study and the association in the skin ageing study suggest its significance in these disease-related biological processes. In otitis media, the association with the BPIFA gene cluster including Bpifa3 may imply its role in the body's response to middle ear inflammation. In skin ageing, the identified association with Bpifa3 points to its potential role in the complex genetic mechanisms underlying skin ageing phenotypes.
In conclusion, Bpifa3 shows promise as a gene involved in multiple disease-related biological processes, particularly in otitis media susceptibility and skin ageing. While direct evidence from KO/CKO mouse models is lacking, the current findings from the cited studies provide initial insights into its potential functions in these areas, which could be further explored in future functional studies.
References：
1. Wong, Chloe, Ng, Jun Yan, Sio, Yang Yie, Chew, Fook Tim. 2025. Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes. In Journal of physiological anthropology, 44, 4. doi:10.1186/s40101-025-00384-9. https://pubmed.ncbi.nlm.nih.gov/39923055/
2. Rye, Marie S, Warrington, Nicole M, Scaman, Elizabeth S H, Blackwell, Jenefer M, Jamieson, Sarra E. 2012. Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood. In PloS one, 7, e48215. doi:10.1371/journal.pone.0048215. https://pubmed.ncbi.nlm.nih.gov/23133572/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
