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Cre Mouse Models for Gene Research
Control gene expression in time and space. The Cre/loxP system lets you modify genes in specific tissues and at defined times, by utilizing the Cre/loxP recombination technique, you can create genetically modified mice that allow for targeted gene modification. Every experiment advances. Every modification matters.
Research-Ready Delivery
Expedited shipping within X hours. Comprehensive health reports included. Direct access to technical support.
Validated Performance
Every line validated through PCR and sequencing. Full breeding documentation provided. Guaranteed germline transmission.
Site-Specific Control
Target genes precisely. Control expression timing. Execute conditional knockouts without developmental interference.
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Overview
Versatile Cre Mouse Lines: Your Gateway to Conditional Genetics
From regular Cre to inducible variants, our validated mouse lines drive tissue-specific gene manipulation across cardiology, neuroscience, and ophthalmology research. Each line comes with comprehensive expression data and breeding validation, empowering your conditional knockout and knockin studies with proven genetic precision.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
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Search and access curated genetically engineered mouse strains
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Genetically engineered mice with specific genes fully inactivated for functional studies.
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Scalable colony expansion with full genotyping support
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Preserve and revive rodent strains on demand
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Full-spectrum analysis for rodents model
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Custom genomic edits with full validation and transgenic support
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Model Selection Made Simple
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Base Strain
Catalog Number
Catalog NumberNameBase StrainExpressing Tissues/CellsAction
C001774Upk2-CreC57BL/6JCyaBladder urothelial and Upk2-positive cells
C001739RCL-Mito-Dendra2C57BL/6JCyaMitochondria
C001759H11-pHsp68-Nfatc1-CreERT2C57BL/6JCyaOsteoclasts, cardiac endocardium, pancreas, liver, ovary, and Nfatc1-positive cells
C001760Ntrk1-CreERT2C57BL/6JCyaSensory neurons, sympathetic neurons, cholinergic neurons, paraventricular nucleus of the thalamus, bone, and Ntrk1-positive cells
C001765Tph2-CreERT2C57BL/6JCyaBrainstem, striatum, hippocampus, prefrontal cortex, cerebellum, and Tph2-positive cells
C001767Ttr-CreERT2C57BL/6JCya Liver, choroid plexus, retinal pigment epithelial cells, hippocampus, pancreas, and Ttr-positive cells
C001768Krt13-CreERT2C57BL/6JCyaOral mucosa, esophageal epithelium, gastric epithelium, urothelium, and Krt13-positive cells
C001763Sim1-iCreC57BL/6JCyaParaventricular nucleus of the hypothalamus, supraoptic nucleus, preoptic periventricular area, amygdala, hippocampus, and Sim1-positive cells
C001764Sprr1a-iCreC57BL/6JCyaSkin, urethra, gastric epithelium, intestine, esophagus, and Sprr1a-positive cells
IR001Pdgfra-CreERT2 RatSDOligodendrocyte Precursor Cells (OPC) or NG2+ Glial Cells in the Spinal Cord and Forebrain
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FAQs
Frequently Asked Questions (FAQs)
Can Cre mice be used for both loss-of-function and gain-of-function studies?
Yes, Cre mice can be used for both loss-of-function (knockout) and gain-of-function (overexpression) studies. By choosing the right mouse model and targeting specific genes, you can explore gene functions in a variety of experimental settings.
What factors influence the efficiency of Cre recombination in mice?
Cre recombination efficiency can be influenced by factors like tissue type, Cre expression levels, and the presence of specific promoter sequences. Our team offers expert advice on optimizing these variables to ensure consistent and reliable results.
How far apart can the loxP sites be for effective gene recombination?
The distance between loxP sites can vary, but for optimal recombination efficiency, they should be relatively close. The ideal distance depends on the specific gene and tissue type you're working with, and we can provide guidance on the best configuration for your research.
What’s the best way to start breeding Cre Lox mice for my research?
Starting with Cre Lox breeding requires careful planning of mouse lines. You'll need to select appropriate Cre and floxed lines and follow strategies to ensure proper genetic recombination. We can assist you with protocols and advice on successful breeding.
How does “Floxing” differ from Cre/loxP gene knockout?
"Floxing" refers to the process of inserting loxP sites around a gene, while Cre/loxP knockout involves using the Cre enzyme to remove the gene between those sites. This allows for targeted and conditional gene modification in specific tissues or stages.
Do all Cre mice models result in gene knockout?
Not all Cre mice are designed for gene knockout. While many models use Cre to delete floxed genes, some are designed for conditional gene activation or other modifications. It’s important to choose the right Cre model based on your research goals.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
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Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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