Ntrk1-CreERT2 mice are generated by inserting an IRES-CreERT2 cassette via genome editing immediately downstream of the TAG stop codon in the mouse Ntrk1 gene. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with mice containing loxP sites, offspring are expected to exhibit Cre-mediated recombination between loxP sites in Ntrk1-positive cells following tamoxifen administration.