H11-pHsp68-Nfatc1-CreERT2 Mouse
Product Name
H11-pHsp68-Nfatc1-CreERT2 Mouse
Product ID
C001759
Strain Name
C57BL/6JCya-Igs2em1(pHsp68-Nfatc1-CreERT2)/Cya
Backgroud
C57BL/6JCya
Examples of Expressing Tissues/Cells
Osteoclasts, cardiac endocardium, pancreas, liver, ovary, and Nfatc1-positive cells
When using this mouse strain in a publication, please cite “H11-pHsp68-Nfatc1-CreERT2 Mouse (Catalog C001759) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Gene Alias
NFAT2, NFATc, NF-ATc, Nfatcb, 2210017P03Rik
NCBI ID
Chromosome
Chr 18
MGI ID
Datasheet
Strain Description
H11-pHsp68-Nfatc1-CreERT2 mice are generated by knocking the Hsp68 minimal promoter-Kozak-CreERT2-WPRE-BGH pA-Mouse Nfatc1 enhancer cassette into the mouse H11 safe harbor locus via genome editing. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with mice containing loxP sites, offspring are expected to undergo Cre-mediated recombination between loxP sites in Nfatc1-positive cells following tamoxifen administration.
Strain Strategy
Figure 1. Diagram of the gene editing strategy for the generation of H11-pHsp68-Nfatc1-CreERT2 mice.
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