Tph2-CreERT2
Product ID:
C001765
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Brainstem, striatum, hippocampus, prefrontal cortex, cerebellum, and Tph2-positive cells
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Strain Description
Tph2-CreERT2 mice are generated via genome editing by replacing the TGA stop codon of the mouse Tph2 gene with a P2A-CreERT2 cassette. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with mice containing loxP sites, offspring are expected to exhibit Cre-mediated recombination between loxP sites in Tph2-positive cells following tamoxifen administration.
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