B6-hMECP2*T158M
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hMECP2*T158M
Product ID
C001569
Gene Name
Background
C57BL/6NCya
Gene Alias
RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “B6-hMECP2*T158M mice (Catalog C001569) were purchased from Cyagen.”
Strain Description
This strain is a humanized MECP2 gene mouse model, generated by replacing the endogenous mouse Mecp2 gene with the human MECP2 gene harboring the T158M mutation through embryonic stem cell targeting techniques. This mutation represents the most common human RTT-associated missense mutation in MECP2. Studies have shown that mice carrying this mutation recapitulate many clinical features of RTT.
Application Area
Research on Rett syndrome (RTT)
Validation Data