With continuous advancement, our searchable Knockout Catalog Model Repository contains over 10k custom knockout (KO) and cKO/floxed strains available to researchers with delivery in as fast as 3 months. We aim to increase mouse model accessibility for researchers worldwide providing high-quality rodent models in the most economic and efficient way.


Read on to discover the wide range of knockout (KO) model resources and support available from Cyagen.


Advantages of Cyagen Knockout Catalog Models

  • AAALAC-Accredited and OLAW Assured
  • No risk of failure: Our catalog features gene knockout mice that have been strictly analyzed to ensure 100% positive knockout.
  • 100% pure B6 background eliminates need for backcrossing – most repositories have mixed backgrounds

>> Search Your Gene of Interest


Knockout mouse models remain vital for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Herein, we provide an overview of Cyagen’s Catalog model services and have collected all of our current resources that aim to support your scientific innovations:


Cyagen Gene of the Week Series

It is well known that genes play a major role in many human diseases - for this reason they are an important research topic in life science and medical fields. How can the public quickly grasp the recent research on disease-related genes? To save the time and energy of researchers, Cyagen has launched its new ‘Gene of the Week’ project, in which we will introduce one specific gene related to human disease each week. This series collects insights on gene research progress and development trends to inspire continued scientific innovations.

>> Check Out Gene of Week Series


Weekly Flash Sales for Live KO/cKO Mice

Cyagen’s Weekly Flash Sales for Knockout Models and Conditional Knockout Models provides a list of specific gene knockout (KO) or conditional knockout (cKO) that are available until the ‘off-the-shelf date’ at a substantial discount. 

Get your ready-to-use models for as low as $1,199 per mouse - shipped in just 2 weeks!

>> Order Now


Cyagen Knockout Model Publications

In under 15 years since its founding, Cyagen has become a leading provider of custom mouse and rat models – delivering over 78,400 models to researchers worldwide and receiving over 4,750 peer-reviewed citations. Our Knockout Catalog Models have been applied in variety of human disease research fields, including virology, atherosclerosis, inflammation, cardiovascular disease, oncology, metabolism, and more.

>> Learn More


Video: Using CRISPR to Develop Knockout Mouse Models for Research

CRISPR, which stands for “Clustered regularly interspaced short palindromic repeats,” works alongside Cas proteins to form the CRISPR-Pro complex – a biological technology originally derived from a prokaryotic adaptive immunity system. To show how this process works, our video introduces the individual components of a CRISPR-Pro complex using the SHANK3 gene as an example.

>> Watch Video


Video: How Knockout Mice are Developed with Traditional Gene Targeting

Watch our newest video to learn about the development process used in generating traditional, ESC-mediated gene knockout mice used in a wide range of genetic and human disease research studies.

>> Watch Video


For a complimentary consultations and quotes, please contact us to get in touch with our model generation experts.