CRO Solutions for Cardiovascular Diseases
Advance cardiovascular drug development with integrated preclinical solutions combining disease-relevant models, in vivo studies, and in vitro capabilities to generate translational evidence from discovery through IND-enabling development.
Cardiovascular Drug Development Solutions
Cyagen provides integrated preclinical CRO solutions for cardiovascular disease research
and drug development, supporting programs in atherosclerosis, hypertension, cardiomyopathy, heart failure,
myocardial infarction, cardiac fibrosis, and vascular disorders. Our capabilities combine validated
cardiovascular animal models with customized in vivo and in vitro studies to evaluate disease mechanisms,
therapeutic efficacy, pharmacodynamic responses, cardiac function, vascular pathology, and relevant biomarkers.
From target validation and model selection to efficacy studies and IND-enabling research, Cyagen helps generate
translational data to advance cardiovascular therapeutics toward clinical development.
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Custom Induction-Based Models
For studies requiring tailored disease phenotypes, Cyagen provides custom
induction-based cardiovascular models, including heart failure with preserved ejection fraction
(HFpEF) models. Induction protocols and study designs can be adapted to specific research
objectives, supporting disease mechanism studies, pharmacology, and therapeutic evaluation.
Ready-to-Use Cardiovascular Disease Models
Cyagen offers a broad range of ready-to-use cardiovascular and cardiometabolic
mouse models, including high-fat diet (HFD)-induced obesity models, target-humanized models,
humanized point mutation models, and other genetically engineered models. By providing established
model options across different disease mechanisms and therapeutic targets, these models enable
researchers to move more efficiently into pharmacology and efficacy studies without starting model
development from scratch.
Base Strain
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INTEGRATED PRECLINICAL CAPABILITIES
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If your desired model isn't listed, our experts are here to help!
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Comprehensive Cardiovascular Efficacy Evaluation
Cyagen provides integrated in vivo assessment for cardiovascular disease research,
covering atherosclerosis and lipid profiling, cardiac function, vascular pathology, hypertension,
and cardiorenal endpoints. These multidimensional readouts support therapeutic efficacy evaluation
and help generate translational evidence for cardiovascular drug development.
Atherosclerosis & Lipid Profiling
- High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholesterol
- Aortic plaque area quantification
- Oil Red O staining
- Hematoxylin and eosin staining
Vascular & Histopathological Evaluation
- Vascular morphology assessment
- Fibrosis evaluation
- Vascular and cardiac remodeling assessment
- Inflammatory marker analysis
Hypertension & Cardiorenal Assessment
- Blood pressure measurement
- Renal function assessment
- Urinary protein analysis
- Blood urea nitrogen
- Serum creatinine
Cardiac Function Assessment
- Echocardiography
- Electrocardiography
- Cardiac output
- Ejection fraction
INTEGRATED PRECLINICAL CAPABILITIES
Looking for tailored in vivo assays to
validate your
candidate?
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In Vitro Cardiovascular Drug Discovery & Mechanistic Studies
Cyagen supports cardiovascular drug discovery with in vitro platforms for
target-based screening, biomarker profiling, and mechanism-of-action studies. These capabilities
enable evaluation of cardiovascular targets, signaling pathways, inflammatory responses, and
cardiorenal mechanisms, helping researchers characterize therapeutic activity and generate
mechanistic evidence before advancing candidates into in vivo studies.
Target-Based Drug Screening
- PCSK9 functional and inhibition assays
- Factor Xa activity and inhibition assays
- PPAR-α/γ activity assays
- 11β-HSD inhibition assays
Cardiovascular Biomarker Profiling
- Inflammatory cytokine profiling using MSD, Luminex, and ELISA
- Inflammatory and vascular biomarkers
- Lipid-related biomarkers
- Cardiac injury or remodeling biomarkers
Cellular Models for Mechanistic Studies
- Renal epithelial and mesangial cell models for cardiorenal research
- cAMP signaling assays for cardiovascular target and pathway evaluation
INTEGRATED PRECLINICAL CAPABILITIES
Need support for in vitro screening or mechanistic
insights?
Case Studies
Key advantages
Integrated End-to-End Cardiovascular CRO Support
From model selection and target validation to in vivo efficacy, mechanistic studies, and IND-enabling research, Cyagen supports cardiovascular programs across the preclinical development workflow.
Disease-Relevant Models for Diverse Cardiovascular Targets
Access ready-to-use and customizable cardiovascular models spanning atherosclerosis, hypertension, cardiomyopathy, heart failure, vascular disorders, and cardiometabolic diseases, including genetically engineered and target-humanized models.
Translational Readouts from Mechanism to Efficacy
Combine cardiac function, lipid profiling, vascular pathology, biomarkers, histopathology, and in vitro functional assays to generate multidimensional evidence for therapeutic efficacy and mechanism of action.
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