Advancing Translational Pain Research: From Humanized Targets to In Vivo Pharmacology
LIVE WEBINAR
Advancing Translational Pain Research: From Humanized Targets to In Vivo Pharmacology
The development of effective analgesics remains challenging due to the complexity and heterogeneity of pain. Robust preclinical models that capture relevant human target biology, disease-associated phenotypes and pharmacological responses are therefore essential for improving translational confidence.
DATE
October 28, 2026 | 8:00 AM PDT
LOCATION
Online | Zoom
Introduction
The development of effective analgesics remains challenging due to the complexity
and heterogeneity of pain. Robust preclinical models that accurately capture relevant human target biology,
disease-associated phenotypes, and pharmacological responses are therefore essential for improving
translational confidence.
This webinar will explore an integrated approach to pain research. We will demonstrate how combining
genetically engineered humanized rodent models with disease-specific pain paradigms and multidimensional
behavioral phenotyping can significantly de-risk your preclinical pipeline.
Summary
Using selected examples from Cyagen’s pain portfolio, we will highlight specific
target-humanized models, including NaV1.7, NaV1.8, CALCA, and CALCRL. A key case study will focus on the
humanized hSCN10A SD rat, illustrating how genetic, transcript-level, and protein-level characterization
integrates directly with disease-relevant pain modeling and pharmacological evaluation.
Furthermore, we will examine Cyagen’s disease-specific neuropathic pain models—such as SNL, CCI, and
chemotherapy-induced peripheral neuropathy (CIPN)—alongside behavioral endpoints spanning mechanical,
thermal, cold, and functional assessments. Join us to discover how bridging target biology, disease
phenotyping, and molecular analysis can generate a comprehensive preclinical evidence package to accelerate
your analgesic drug discovery.
Target Audience
- Pain & Neuroscience Researchers
- Preclinical Drug Discovery Scientists
- Ion Channel & Pain Target Researchers
- Migraine & Neuropeptide Researchers
- Pharmaceutical & Biotechnology Scientists
- Scientists Selecting or Outsourcing Animal Models
Key Learning Objectives
- Establish Confidence in Engineered Models: Discover how molecular characterization of human and mouse gene expression validates key humanized models.
- Integrate Disease-Relevant Modeling: Dive into a key case study on the humanized hSCN10A SD rat to see how target biology directly informs pharmacological evaluation.
- Evaluate Neuropathic Pain Paradigms: Examine disease-specific models, including SNL, CCI, and CIPN.
- Utilize Multidimensional Endpoints: Learn how to implement robust in vivo pharmacology studies using mechanical, thermal, cold, and functional assessments.
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