hACE2-All CDS-B6J
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
hACE2-All CDS-B6J
Product ID
C001191
Gene Name
Background
C57BL/6JCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.”
Strain Description
This strain is a mouse Ace2 gene humanization model that uses gene editing technology to replace the endogenous mouse Ace2 gene sequence with human ACE2 CDS, preserving the mouse signal peptide sequence and achieving hACE2 expression directed by the endogenous mouse Ace2 regulatory element. This gene is located on the mouse chromosome X and homozygous females and heterozygous males are viable and fertile.
Application Area
COVID-19 and related diseases research
COVID-19 vaccine and antibody drug evaluation
Validation Data
References
Research square
Mar, 2022
A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variants
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Signal Transduction and Targeted Therapy
Mar, 2023
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
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Small Methods
May, 2022
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape
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bioRxiv
Jul, 2022
Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models
Read More
nature microbiology
Aug, 2022
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
Read More
EMBO Molecular Medicine
Mar, 2022
SARS-CoV-2 Spike Spurs Intestinal Inflammation via VEGF Production in Enterocytes
Read More