hACE2-All CDS-B6J
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Strain Description
This strain is a mouse Ace2 gene humanization model that uses gene editing technology to replace the endogenous mouse Ace2 gene sequence with human ACE2 CDS, preserving the mouse signal peptide sequence and achieving hACE2 expression directed by the endogenous mouse Ace2 regulatory element. This gene is located on the mouse chromosome X and homozygous females and heterozygous males are viable and fertile.
Application Area
COVID-19 and related diseases research
COVID-19 vaccine and antibody drug evaluation
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