hACE2-All CDS-B6J Mouse
Product Name
hACE2-All CDS-B6J Mouse
Product ID
C001191
Strain Name
C57BL/6JCya-Ace2em1(hACE2)/Cya
Backgroud
C57BL/6JCya
Status
When using this mouse strain in a publication, please cite “hACE2-All CDS-B6J Mouse (Catalog C001191) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
ACE2
Gene Alias
ACEH
NCBI ID
Chromosome
Chr X (Human)
MGI ID
Datasheet
Strain Description
Angiotensin-converting enzyme 2 (ACE2) is the predominant cell surface receptor for SARS-CoV-2 virus infection in humans, but due to interspecies differences, the SARS-CoV-2 virus is unable to bind to ACE2 receptors in most wild-type rodents, including mice. Replacement of mouse Ace2 with human ACE2 by gene editing techniques resulted in humanized ACE2 mice (hACE2) that stably express human ACE2 receptors for COVID-19 studies.
This strain is a mouse Ace2 gene humanization model that uses gene editing technology to replace the endogenous mouse Ace2 gene sequence with human ACE2 CDS, preserving the mouse signal peptide sequence and achieving hACE2 expression directed by the endogenous mouse Ace2 regulatory element. This gene is located on the mouse chromosome X, and homozygous females and heterozygous males are viable and fertile.
Strain Strategy
Figure 1. Gene editing strategy for hACE2-All CDS-B6J mice.
Application Area
COVID-19 and related diseases research;
COVID-19 vaccine and antibody drug evaluation.
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