Rag1 KO
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Genotype
Sex
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Basic Information
Model Name
Rag1 KO
Product ID
C001197
Gene Name
Background
C57BL/6NCya
Gene Alias
Rag-1
Classification
Immunodeficient Mouse Models
NCBI ID
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “Rag1 KO mice (Catalog C001197) were purchased from Cyagen.”
Strain Description
The Rag1-KO Mouse is a RAG1-deficient model that exhibits smaller lymphoid organs and does not contain mature B and T lymphocytes, the arrest of B and T cell differentiation occurs at an early stage and correlates with the inability to perform V(D)J recombination. The homozygote Rag1-KO mice developed normally and were fertile.
Application Area
Used for transplantation of primary cells, hematoma cells, and other tumor types
Validation Data
References
Aging Cell
Mar, 2024
MicroRNA-7 deficiency ameliorates d-galactose-induced aging in mice by regulating senescence of Kupffer cells
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Journal of Cerebral Blood Flow & Metabolism
Dec, 2022
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke
Read More
Immunity
Dec, 2024
Hypoxia-inducible factor 2a promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
Read More
Nature Microbiology
May, 2024
Mycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Read More
Journal of Cerebral Blood Flow and Metabolism
Dec, 2022
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
Read More
Immunity
Nov, 2024
Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
Read More