Il12rb1 KO Mouse
Product Name
Il12rb1 KO Mouse
Product ID
C001214
Strain Name
C57BL/6NCya-Il12rb1em1/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “Il12rb1 KO Mouse (Catalog C001214) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Il12rb1
Gene Alias
CD212, IL-12R[b], IL-12R-beta-1
NCBI ID
Chromosome
Chr 8 (Mouse)
MGI ID
Datasheet
Strain Description
The Il12rb1 gene encodes a type I transmembrane protein that belongs to the hematopoietin receptor superfamily. This protein binds to interleukin-12 (IL-12) with low affinity and participates in IL-12 signal transduction. When combined with IL12RB2, it forms a functional high-affinity receptor for IL-12. The co-expression of this protein and IL12RB2 has been shown to create high-affinity IL-12 binding sites and reconstruct IL-12-dependent signal transduction. Mutations in the Il12rb1 gene impair the development of T lymphocytes that produce interleukin-17 and increase susceptibility to mycobacterial and Salmonella infections. Il12rb1 knockout (KO) homozygous mice exhibit reduced serum levels of interferon-gamma (IFN-γ) in response to recombinant IL-12 or lipopolysaccharide (LPS) treatment. Additionally, splenocytes from these mice activated by concanavalin A (ConA) in response to IL-12 cannot proliferate or secrete IFN-γ[1]. These homozygous mice are viable and fertile.
Reference
Wang X, Jia L, Liu Y, Wang J, Qiu C, Li T, Zhang W, Zhu Z, Wu J, Wan Y. Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice. Vaccines (Basel). 2022 Jul 19;10(7):1147.
Strain Strategy
Figure 1. Diagram of the gene editing strategy for the generation of Il12rb1 KO mice. The Il12rb1 gene is located on chromosome 8 in mice. Using gene-editing technology, exons 2~8 of this gene were knocked out.
Application Area
Immune System-Related Research
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