Alox5 KO
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Strain Description
This strain is a mouse Alox5 gene deletion model, achieved by using gene editing technology to knock out the homologous gene of human ALOX5 in mice. According to literature reports, these mice exhibit increased total adipose tissue weight, plasma VLDL/LDL cholesterol, and bone mineral density. Their spleens are typically smaller than those of wild-type mice, and they exhibit reduced inflammatory responses and abnormalities in immunophysiology. These homozygous Alox5 KO mice are viable and fertile.
Application Area
Research on hematopoietic regulation
Pathological research on myeloid leukemia
Research on the mechanism of atherosclerosis
Research on the regulation of immune and inflammatory responses
Research on other hematological tumors
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