hACE2-EGFP
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
hACE2-EGFP
Product ID
C001226
Gene Name
Background
C57BL/6NCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “hACE2-EGFP mice (Catalog C001226) were purchased from Cyagen.”
Strain Description
In this strain, the mouse endogenous Ace2 gene sequence was replaced with the coding sequence (CDS) of the human ACE2 gene, while retaining the sequence encoding the mouse ACE2 protein signal peptide. This resulted in the expression of the hACE2 protein under the control of the endogenous mouse Ace2 regulatory elements. In addition, an enhanced green fluorescent protein (EGFP) expression cassette was inserted into the model to allow tracking of hACE2 expression. The integration site of the hACE2 is located on the mouse chromosome X. Homozygous female and hemizygous male hACE2-EGFP mice are viable and fertile.
Application Area
Cardiovascular function research
SARS-CoV-2 infection mechanism research
SARS-CoV-2 vaccine development evaluation
SARS-CoV-2 prevention and treatment drug screening evaluation
SARS-CoV-2 antibody drug development validation
Validation Data