Il10 KO
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Genotype
Sex
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Basic Information
Model Name
Il10 KO
Product ID
C001230
Gene Name
Background
C57BL/6NCya
Gene Alias
CSIF; If2a; Il-10
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “Il10 KO mice (Catalog C001230) were purchased from Cyagen.”
Strain Description
This strain is an Il10 gene knockout (Il10 KO) mouse, in which the Il10 gene homologous to the human IL10 gene has been knocked out in mice using gene editing technology. Homozygous Il10-KO mice do not produce the anti-inflammatory cytokine IL-10 and can survive and reproduce under specific pathogen-free (SPF) conditions. This strain is maintained in a high-standard SPF environment in Cyagen facilities, and its phenotype differs from that of Il10 knockout mice raised in conventional mouse facilities as reported in the literature. For example, the development of colitis in this model may be slow or non-spontaneous, but the introduction of microbes or fecal microbiota may cause rapid development of colitis in adult animals. Homozygous Il10 KO mice are viable and fertile.
Application Area
Research in areas including inflammatory bowel disease (IBD), such as Crohn’s disease (CD) and colitis, cancer, congenital and adaptive immune diseases, and many other inflammation or autoimmune research fields.
Validation Data