This strain is a Tlr3 gene knockout (Tlr3 KO) mouse, which uses gene editing technology to knock out the Tlr3 gene in mice homologous to the human TLR3 gene. Homozygous Tlr3 KO mice are viable and fertile. Research shows that, unlike the macrophages of wild-type mice, the macrophages of Tlr3 KO mice cannot produce the inflammatory cytokines IFN-α or IFN-β when attacked by polyinosinic-polycytidylic acid. Primary splenocytes isolated from homozygous Tlr3 KO mice are unresponsive to viral dsRNA and have reduced IL-6 production.