Tlr4 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Tlr4 KO
Product ID
C001234
Gene Name
Background
C57BL/6NCya
Gene Alias
Lps; Ly87; Ran/M1; Rasl2-8
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
4
Document
Note: When using this mouse strain in a publication, please cite “Tlr4 KO mice (Catalog C001234) were purchased from Cyagen.”
Strain Description
This strain is a Tlr4 knockout (Tlr4 KO) mouse model utilizing gene editing technology to knock out the Tlr4 gene homologous to the human TLR4 gene in mice. Homozygous Tlr4 KO mice are viable and fertile and exhibit a variety of phenotypes associated with immune responses, including hyporesponsiveness to bacterial lipopolysaccharide (LPS) and elevated levels of respiratory syncytial virus.
Application Area
Innate immune response studies
PAMP and DAMP studies
Respiratory syncytial virus research
Inflammatory response, anti-viral infection and tumor therapy studies
Validation Data