This strain is a Tlr2 gene knockout (Tlr2 KO) mouse, which uses gene editing technology to knock out the Tlr2 gene in mice homologous to the human TLR2 gene. Homozygous Tlr2 KO mice are viable and fertile. It has been reported that the cells of this mouse have defects in TLR2-mediated signal transduction, causing the mouse to exhibit abnormalities in immune responses against bacterial and viral infections. Therefore, Tlr2 KO is often used to study the role of TLR2 in pathogen recognition and the activation of innate immunity.