Nod2 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Nod2 KO
Product ID
C001264
Gene Name
Background
C57BL/6NCya
Gene Alias
CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Nod2 KO mice (Catalog C001264) were purchased from Cyagen.”
Strain Description
This strain is a Nod2 gene knockout (Nod2 KO) mouse, which uses gene editing technology to knock out the Nod2 gene in mice homologous to the human NOD2 gene. Homozygous Nod2 KO mice are viable and fertile. Research shows that the knockout of the Nod2 gene leads to abnormal morphology and physiology of the immune system in mice and increases their susceptibility to induced colitis. Therefore, the Nod2 KO mouse model can be used for research on inflammatory bowel disease (IBD), Crohn’s disease (CD), irritable bowel syndrome (IBS), and other intestinal or inflammatory diseases as well as other Nod2-related diseases.
Application Area
Research on a variety of diseases, including Crohn’s disease (CD), other inflammatory bowel diseases (IBD), Parkinson’s disease (PD), myocardial infarction, antithrombotic formation, myocardial ischemia, and tumors
Validation Data
References