Foxj1 KO Mouse
Product Name
Foxj1 KO Mouse
Product ID
C001265
Strain Name
C57BL/6NCya-Foxj1em1/Cya
Backgroud
C57BL/6NCya
When using this mouse strain in a publication, please cite “Foxj1 KO Mouse (Catalog C001265) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Gene Alias
Hfh4, HFH-4, FKHL-13
NCBI ID
Chromosome
Chr 11
MGI ID
Datasheet
Strain Description
Foxj1 (forkhead-box J1), also known as hepatocyte nuclear factor-3 (HNF-3) or forkhead homologue-4 (HFH-4), is a member of the forkhead-box transcription factor family, a class of transcription factors with a winged helix structure that binds to DNA. The Foxj1 factor plays a major regulatory role in controlling the transcription process of motile cilia synthesis. Airway cilia quickly clear airway mucus by swinging, playing a role in resisting pathogen invasion. It also has an effect on the left-right axis asymmetry of organ development during the embryonic period.
This strain is a Foxj1 gene knockout mouse model. Studies have shown that Foxj1 KO mice exhibit left-right asymmetric development and airway ciliated epithelium is lost in adult mice [1]. The heterozygous Foxj1 KO mice are viable, while the homozygous mice are lethal.
Reference
Stauber M, Weidemann M, Dittrich-Breiholz O, et al. Identification of FOXJ1 effectors during ciliogenesis in the fetal respiratory epithelium and embryonic left-right organiser of the mouse[J]. Developmental Biology, 2017, 423(2):170-188.
Strain Strategy
Foxj1 gene is located on mouse chromosome 11 and Exons 2-3 was knocked out to obtain the Foxj1 KO Mice.
Figure 1. Diagram of the gene editing strategy for the generation of Foxj1 KO mice.
Application Area
Research on Kartagener syndrome；
Research on primary ciliary dyskinesia.
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