Usp26 KO Mouse
Product Name
Usp26 KO Mouse
Product ID
C001266
Strain Name
C57BL/6NCya-Usp26em1/Cya
Backgroud
C57BL/6NCya
Reproduction
Hemizygous male x Homozygous female
Status
When using this mouse strain in a publication, please cite “Usp26 KO Mouse (Catalog C001266) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Gene Alias
--
NCBI ID
Chromosome
Chr X
MGI ID
Datasheet
Strain Description
Ubiquitin-Specific Protease 26 (USP26), which belongs to the ubiquitination-specific processing protease family, is a deubiquitinating enzyme with histidine (His) and cysteine (Cys) structural domains. the USP26 gene is specifically expressed in testicular tissue as well as in the blood-testis barrier, and premeiotic spermatogonia during spermatogenesis The gene is expressed in the spermatogonia before meiosis during spermatogenesis, including primitive A-, Ap- and B-type spermatogonia. The main diseases associated with USP26 are male infertility, including weak teratozoospermia, non-obstructive azoospermia (NOA), Sertoli cell-only syndrome (SCOS), and Klinefelter syndrome (KS).
This model is a Usp26 gene-knockout mouse. Homozygous mice of this strain are viable, while homozygous male mice are infertile.
Strain Strategy
The Usp26 gene is located on mouse chromosome X, and Exon 9 of this gene was deleted.
Figure 1. Diagram of the gene editing strategy for the generation of Usp26 KO mice.
Application Area
This strain can be used in the study of male hypo fertility associated with defective spermatogenesis including Creutzfeldt-Jakob syndrome
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