Ifnar1 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Ifnar1 KO
Product ID
C001268
Gene Name
Background
C57BL/6NCya
Gene Alias
Ifar; Ifrc; Ifnar; Infar
Classification
Immunodeficient Mouse Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
16
Document
Note: When using this mouse strain in a publication, please cite “Ifnar1 KO mice (Catalog C001268) were purchased from Cyagen.”
Strain Description
This strain represents a model of Ifnar1 knockout (KO), constructed by the deletion of exon 2 (E2) of the mouse Ifnar1 gene. This modification leads to a deficiency in the function of type I IFN receptors, resulting in a diminished immune response, heightened susceptibility to viral infections, and a decreased immune response to immunostimulatory DNA. Homozygous Ifnar1 KO mice are viable and fertile.
Application Area
Antiviral immune responses, as well as interferon stimulation and JAK-STAT signaling
Validation Data
References
Nature Communications
Oct, 2024
A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice
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EMBO Journal
Mar, 2022
Mouse circulating extracellular vesicles contain virus‐derived siRNAs active in antiviral immunity
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Emerg Microbes Infect
Dec, 2020
The activation of antiviral RNA interference not only exists in neural progenitor cells but also in somatic cells in mammals
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Immunity
Nov, 2023
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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FASEB J.
Sep, 2020
The intestinal microbial metabolite desaminotyrosine is an anti-inflammatory molecule that modulates local and systemic immune homeostasis
Read More