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NKG Mouse
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NKG Mouse
Product Name
NKG Mouse
Product ID
C001316
Strain Name
NOD.Cg-PrkdcscidIl2rgem1cya/Cya
Backgroud
NOD.Cg
Coat Color
White
Breeding Strategy
Sibling x Sibling
When using this mouse strain in a publication, please cite “NKG Mouse (Catalog C001316) were purchased from Cyagen.”
Immunodeficient Mice
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Immunodeficient Mice
Basic Information
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Basic Information
Gene Name
Il2rg
Gene Alias
gc, p64, [g]c, CD132, gamma(c)
NCBI ID
16186
Chromosome
Chr X
MGI ID
--
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Datasheet
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Strain Description
NKG mice are a kind of severe immunodeficient mice generated by Cyagen by deleting the Il2rg gene from NOD-Scid genetic background mice. NKG mice exhibit deficiency of mature T cells, B cells, and functional NK cells, reduced complement activity, and weak phagocytosis of human-derived cells by macrophages, which are well suited for transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), adult stem cells and tissues, and patient-derived xenograft (PDX).
NKG mice are currently recognized as one of the models with the highest degree of immunodeficiency. They are an excellent model that can be widely used for research in the fields of oncology, immunity, autoimmune diseases, immunotherapy, vaccines, graft-versus-host disease (GvHD), and drug safety evaluation.
Application Area
Immune system and tumor immunity research;
Hematopoietic development and blood disorders research;
Infectious disease studies such as HIV and AIDS;
Tumor transplantation and anti-tumor efficacy studies;
CDX, PDX, GvHD, and humanized immune system (HIS) research.
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