NKG
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Strain Description
NKG mice are a kind of severe immunodeficient mice generated by Cyagen by deleting the Il2rg gene from NOD-Scid genetic background mice. NKG mice exhibit deficiency of mature T cells, B cells, and functional NK cells, reduced complement activity, and weak phagocytosis of human-derived cells by macrophages, which are well suited for transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), adult stem cells and tissues, and patient-derived xenograft (PDX).
Application Area
Immune system and tumor immunity research
Hematopoietic development and blood disorders research
Infectious disease studies such as HIV and AIDS
Tumor transplantation and anti-tumor efficacy studies
CDX, PDX, GvHD, and humanized immune system (HIS) research
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