NKG
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
NKG
Product ID
C001316
Gene Name
Background
NOD.Cg
Gene Alias
gc; p64; [g]c; CD132; gamma(c)
Classification
Immunodeficient Mouse Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “NKG mice (Catalog C001316) were purchased from Cyagen.”
Strain Description
NKG mice are a kind of severe immunodeficient mice generated by Cyagen by deleting the Il2rg gene from NOD-Scid genetic background mice. NKG mice exhibit deficiency of mature T cells, B cells, and functional NK cells, reduced complement activity, and weak phagocytosis of human-derived cells by macrophages, which are well suited for transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), adult stem cells and tissues, and patient-derived xenograft (PDX).
Application Area
Immune system and tumor immunity research
Hematopoietic development and blood disorders research
Infectious disease studies such as HIV and AIDS
Tumor transplantation and anti-tumor efficacy studies
CDX, PDX, GvHD, and humanized immune system (HIS) research
Validation Data
References
Acta Biomaterialia
Sep, 2023
PTT/ PDT-induced microbial apoptosis and wound healing depend on immune activation and macrophage phenotype transformation
Read More
BMC Cancer
Sep, 2022
MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
Read More
Stem Cell Research
Dec, 2024
Human induced pluripotent stem cell line (FDHSi005-A) derived from a patient with a deep intronic variant in the GNE gene
Read More
Frontiers in Immunology
Jan, 2025
A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells
Read More
Cancer Immunology Research
Jan, 2023
Enhancing the Antitumor Immunity of T Cells by Engineering the Lipid-Regulatory Site of the TCR/CD3 Complex
Read More
预印本
Mar, 2023
Extensive Dysregulation of SLK Splicing in Cancers Impacts Metastasis
Read More
International Journal of Nanomedicine
Oct, 2023
The Therapeutic Effects of MUC1-C shRNA@Fe3O4 Magnetic Nanoparticles in Alternating Magnetic Fields on Triple-Negative Breast Cancer
Read More
Heliyon
Jan, 2024
The construction, validation and promotion of the nomogram prognosis prediction model of UCEC, and the experimental verification of the expression and knockdown of the key gene GPX4
Read More
ACS Materials Letters
Aug, 2024
Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies
Read More
Molecular Therapy
Feb, 2025
Single-cell data-driven design of armed oncolytic virus to boost cooperative innate-adaptive immunity against cancer
Read More
Signal Transduction and Targeted Therapy
Jun, 2024
Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer
Read More
Discover Oncology
Apr, 2024
Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells
Read More
International Journal of Biological Sciences
Jan, 2025
SERINC2-mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion
Read More
Cancers
Dec, 2022
Role of Epidermal Growth Factor Receptor-Specific CAR-T Cells in the Suppression of Esophageal Squamous Cell Carcinoma
Read More
Journal of Translational Medicine
Feb, 2024
Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer
Read More
Taylor & Francis
Oct, 2024
Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo
Read More
MedComm
Oct, 2024
Feedback loop LINC00511–YTHDF2–SOX2 regulatory network drives cholangiocarcinoma progression and stemness
Read More
Microbial Cell Factories
May, 2023
Manufacture and evaluation of a HER2-positive breast cancer immunotoxin 4D5Fv-PE25
Read More
Pharmacological Research
Sep, 2024
Developing patient-derived organoids to demonstrate JX24120 inhibits SAMe synthesis in endometrial cancer by targeting MAT2B
Read More
The EMBO Journal
Jan, 2025
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis
Read More
ACS Pharmacology & Translational Science
Nov, 2024
Gallium-68 Labeled Positron Emission Computed Tomography Tracer Targeting Glypican-3 with High Contrast for Hepatocellular Carcinoma Imaging
Read More
Materials Today Bio
Jun, 2024
Enhancing glioma-specific drug delivery through self-assembly of macrophage membrane and targeted polymer assisted by low-frequency ultrasound irradiation
Read More
Nature Communications
Oct, 2024
Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer
Read More
British Journal of Haematology
Jul, 2024
Development of novel humanized CD19/BAFFR bicistronic chimeric antigen receptor T cells with potent antitumor activity against B-cell lineage neoplasms
Read More
PLoS ONE
Sep, 2024
TFAB002s, novel CD20-targeting T cell-dependent bispecific Fab-FabCH3 antibodies, exhibit potent antitumor efficacy against malignant B-cell lymphoma
Read More
Advanced Science
Jan, 2025
A Novel 167-Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination
Read More
Nature Communications
Dec, 2024
An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control
Read More