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B6-hCD3
Product ID:
C001325
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
B6-hCD3
Product ID
C001325
Gene Name
CD3E, CD3D, CD3G
Background
C57BL/6NCya
Gene Alias
T3E; TCRE; IMD18; CD3epsilon; T3D; IMD19; CD3DELTA; CD3-DELTA; T3G; IMD17; CD3GAMMA; CD3-GAMMA
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
NCBI ID
916, 915, 917
Phenotype
MGI:88332, MGI:88331, MGI:88333
Chromosome
--
More
Rare Disease Data Center >>
Datasheet
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Note
Note: When using this mouse strain in a publication, please cite “B6-hCD3 mice (Catalog C001325) were purchased from Cyagen.”
Strain Description
This strain is a humanized mouse model of CD3 in which the genes encoding the human CD3 complex were integrated into the mouse Cd3 gene locus through embryonic stem cell (ES) targeting technology to express human CD3 in mice. This model can be used for the mechanism research of T cell activation and antigen recognition, as well as the development, verification, and evaluation of CD3-targeted drugs in immunosuppressive therapy for autoimmune diseases.
Application Area
Area
Elucidation of the molecular mechanisms of T cell activation and antigen recognition
Area
Development and evaluation of CD3-targeted immunotherapies for autoimmune diseases
Area
Discovery and preclinical validation of novel CD3-targeted drugs
Validation Data
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