BALB/c-Ighm KO Mouse
Product Name
BALB/c-Ighm KO Mouse
Product ID
C001341
Strain Name
BALB/cAnCya-Ighmem1/Cya
Backgroud
BALB/cAnCya
Status
When using this mouse strain in a publication, please cite “BALB/c-Ighm KO Mouse (Catalog C001341) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Strain Description
Immunoglobulin M (IgM) is a basic antibody secreted by B cells and is by far the largest antibody found in the human circulatory system and the first to react to antigens, with the spleen being the largest producer of IgM. Due to its extremely large molecular weight, IgM is very effective in antigen agglutination reactions. In the early stages of B-cell-mediated (humoral) immunity, IgG is not sufficient and IgM is primarily responsible for the clearance of pathogens. As the first circulating antibody to respond to the initial encounter with a foreign antigen, IgM concentration in the blood decreases rapidly due to clearance, and therefore, Immature B cells begin to express membrane IgM (mIgM), but the BCR of immature B cells that express only mIgM can react with membrane self-antigens on the surface of bone marrow cells to block the differentiation of the cells into mature B cells, which is one of the mechanisms by which autoimmune tolerance develops.
This strain is an Ighm-deletion model, and the homozygous mice lack mature B cells but develop normally and are fertile.
Strain Strategy
Exons 1~6 of the mouse Ighm gene were deleted by gene editing technology.
Figure 1. Gene editing strategy for BALB/c-Ighm KO mice.
Application Area
Immunology;
Inflammation;
Autoimmunity research.
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