B6J-Ighm Ighd-DKO Mouse
Product Name
B6J-Ighm Ighd-DKO Mouse
Product ID
C001342
Strain Name
C57BL/6JCya-Ighmem1lghdem1/Cya
Backgroud
C57BL/6JCya
When using this mouse strain in a publication, please cite “B6J-Ighm Ighd-DKO Mouse (Catalog C001342) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
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Gene Alias
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NCBI ID
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Chromosome
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Datasheet
Strain Description
Surface membrane immunoglobulin (SmIg) of the B cell membrane is a receptor that specifically recognizes antigens of B cells, and it is also an important characteristic marker of B cells. Early immature B cells express immunoglobulin M (IgM), while mature B cells express both membrane IgM (mIgM) and membrane IgD (mIgD).
This strain is a mouse Ighm gene and Ighd gene double knockout model. Homozygous B6J-Ighm Ighd-DKO mice lack mature B cells and can be used as an animal model of B cell immunodeficiency.
Strain Strategy
Exons 1~6 of the mouse Ighm gene to exons 1~5 of the mouse Ighd gene were deleted.
Figure 1. Gene editing strategy for B6J-Ighm Ighd-DKO mice.
Application Area
Immunology;
Inflammation;
Autoimmunity research.
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