B6-Ighj KO
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-Ighj KO
Product ID
C001344
Gene Name
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Background
C57BL/6JCya
Gene Alias
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Classification
Immunodeficient Mouse Models
NCBI ID
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Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-Ighj KO mice (Catalog C001344) were purchased from Cyagen.”
Strain Description
This strain is an Ighj-deletion model, in the homozygous B6-Ighj KO mice, the J-segment of the Ig heavy chain locus is completely deleted, resulting in the inability of the cell to produce a recombinant version of the complete heavy chain variable region. The B cells of B6-Ighj KO mice have undergone dramatic changes in the developmental process and cell number, which can be used as an animal model of B-cell immune deficiency. B6-Ighj KO mice retain other immune cells except for B cells, so the presence of other immune cells can be detected in B6-Ighj KO mice.
Application Area
Immunological, inflammatory, and autoimmune diseases
Validation Data
References