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B6-Il2rg KO
Product ID:
C001374
Background:
C57BL/6JCya
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Strain Description
B6-Il2rg KO mice were obtained by knocking out the expression of the Il2rg gene in C57BL/6JCya mice, which are severely deficient in B and T cells in peripheral blood and bone marrow and partially deficient in the spleen, while the mice show a severe immunodeficient phenotype with almost complete absence of NK cells in peripheral blood, spleen, and bone marrow. This strain can be used for research in the fields of oncology, immunology, infectious disease, and stem cell biology.
Application Area
Area
Oncology: Research of tumor growth and metastasis and screening of anti-tumor drugs
Area
Immunology: Research on the proliferation of immune cells and the mechanism of immune diseases
Area
Infectious diseases: Research on the pathogenesis of viral and bacterial infectious diseases
Area
Stem cell biology: Research on human-derived stem cell transplantation
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