B6-Il2rg KO
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-Il2rg KO
Product ID
C001374
Gene Name
Background
C57BL/6JCya
Gene Alias
gc; p64; [g]c; CD132; gamma(c)
Classification
Immunodeficient Mouse Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “B6-Il2rg KO mice (Catalog C001374) were purchased from Cyagen.”
Strain Description
B6-Il2rg KO mice were obtained by knocking out the expression of the Il2rg gene in C57BL/6JCya mice, which are severely deficient in B and T cells in peripheral blood and bone marrow and partially deficient in the spleen, while the mice show a severe immunodeficient phenotype with almost complete absence of NK cells in peripheral blood, spleen, and bone marrow. This strain can be used for research in the fields of oncology, immunology, infectious disease, and stem cell biology.
Application Area
Oncology: Research of tumor growth and metastasis and screening of anti-tumor drugs
Immunology: Research on the proliferation of immune cells and the mechanism of immune diseases
Infectious diseases: Research on the pathogenesis of viral and bacterial infectious diseases
Stem cell biology: Research on human-derived stem cell transplantation
Validation Data