Cdh16-MerCreMer
Product ID:
C001432
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Cortical tubular epithelium of the kidney
Product Type
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Genotype
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Basic Information
Model Name
Cdh16-MerCreMer
Product ID
C001432
Gene Name
Background
C57BL/6JCya
Gene Alias
--
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Cdh16-MerCreMer mice (Catalog C001432) were purchased from Cyagen.”
Strain Description
Cdh16-MerCreMer mice were generated by inserting a tamoxifen-inducible Cre recombinase protein (MerCreMer) expression element downstream of the stop codon of the mouse Cdh16 gene. The expression pattern of MerCreMer mirrored that of the endogenous gene, while not affecting its expression. Before induction, MerCreMer was localized to the cytoplasm, and only after tamoxifen treatment could it translocate to the nucleus to exert its recombination effect. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the renal tubular epithelial cells of the offspring following tamoxifen induction.
Validation Data