Cdh16-MerCreMer Mouse
Product Name
Cdh16-MerCreMer Mouse
Product ID
C001432
Strain Name
C57BL/6JCya-Cdh16em1(IRES-MerCreMer)/Cya
Backgroud
C57BL/6JCya
When using this mouse strain in a publication, please cite “Cdh16-MerCreMer Mouse (Catalog C001432) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Gene Alias
--
NCBI ID
Chromosome
Chr 8
MGI ID
Datasheet
Strain Description
The Cadherin 16 (CDH16) gene encodes a calcium-dependent, membrane-associated glycoprotein that belongs to the calmodulin superfamily. This cell adhesion molecule is involved in embryonic development and cell growth and is exclusively expressed in the kidney, where it is also known as kidney-specific calmodulin (ksp-calmodulin). CDH16 functions as a major mediator of homotypic cell recognition and plays a role in directing tissue morphogenesis, particularly in the formation of renal tubules during embryonic development.
Cdh16-MerCreMer mice were generated by inserting a tamoxifen-inducible Cre recombinase protein (MerCreMer) expression element downstream of the stop codon of the mouse Cdh16 gene. The expression pattern of MerCreMer mirrored that of the endogenous gene. Before induction, MerCreMer was localized to the cytoplasm, and only after tamoxifen treatment could it translocate to the nucleus to exert its recombination effect. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the renal tubular epithelial cells of the offspring following tamoxifen induction.
Strain Strategy
The "IRES-MerCreMer" gene expression element was inserted into the 3'UTR of the mouse Cdh16 gene using gene editing technology.
Figure 1. Diagram of the gene editing strategy for the generation of Cdh16-MerCreMer mice.
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