Vil1-MerCreMer
Product ID:
C001433
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Intestinal villi and crypt epithelial cells
Product Type
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Basic Information
Model Name
Vil1-MerCreMer
Product ID
C001433
Gene Name
Background
C57BL/6JCya
Gene Alias
Vil
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “Vil1-MerCreMer mice (Catalog C001433) were purchased from Cyagen.”
Strain Description
Vil1-MerCreMer mice were generated by inserting a Tamoxifen-inducible Cre recombinase protein MerCreMer gene expression element controlled by the mouse Vil1 promoter into the mouse H11 safe harbor site. Before induction, MerCreMer is only present in the cytoplasm and can only enter the nucleus to exert its recombination effect after Tamoxifen treatment. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the villous and crypt epithelial cells of the small and large intestines of the offspring after Tamoxifen induction. The onset of endogenous mouse Vil1 gene expression is at 9.0dpc, and the onset of Cre recombinase expression in this strain is approximately 12.5dpc.
Validation Data