This strain was constructed using gene editing technology. Part of the exon 1 coding sequence was replaced with the “Cre-rBG pA” cassette. Nppa-Cre mice can specifically express Cre recombinase in ventricular and atrial cardiomyocytes. When this strain is crossed with mice containing loxP sites, the offspring can produce sequence recombination between loxP sites mediated by Cre recombinase in cardiomyocytes. The heterozygous Nppa-Cre mice are viable and fertile.