Sftpc-MerCreMer mice were generated to integrate the tamoxifen-inducible MerCreMer recombinase expression element into the 3’UTR of the mouse Sftpc gene. This mimics the expression pattern of the endogenous gene while maintaining Sftpc expression. When bred with mice carrying a loxP site-flanked sequence, Cre recombinase-mediated recombination of the flanked sequence occurs in type II alveolar cells, following tamoxifen induction.