Col1a2-iCre
Product ID:
C001528
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Fibroblasts
Product Type
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Genotype
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Basic Information
Model Name
Col1a2-iCre
Product ID
C001528
Gene Name
Background
C57BL/6JCya
Gene Alias
oim; Cola2; Cola-2; Col1a-2
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “Col1a2-iCre mice (Catalog C001528) were purchased from Cyagen.”
Strain Description
The collagen alpha-2(I) chain (COL1A2) gene encodes the pro-alpha2 chain of type I collagen. Type I collagen is a fibrous structural protein that is widely present in most connective tissues, particularly in the extracellular matrix of bone, cornea, dermis, and tendons. In this model, the P2A-iCre element is knocked into the mouse Col1a2 gene at the TAA stop codon. Its specific expression is regulated by the mouse Col1a2 gene. When crossed with mice containing loxP sites, the offspring mice can undergo sequence recombination between loxP sites in fibroblast cells, mediated by the Cre recombinase.
Validation Data