B6-hCOL7A1*c.6527dupC
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCOL7A1*c.6527dupC
Product ID
C001538
Gene Name
Background
C57BL/6NCya
Gene Alias
EBD1; EBR1; EBDCT; NDNC8
Classification
Full-Gene Humanized Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “B6-hCOL7A1*c.6527dupC mice (Catalog C001538) were purchased from Cyagen.”
Strain Description
This strain is a disease model constructed by introducing a common recurrent mutation (c.6527dupC) of the COL7A1 gene in human diseases into the mouse Col7a1 humanized model (Catalog Number: C001428). The homozygous B6-hCOL7A1*c.6527dupC mice exhibit a disease phenotype similar to human Dystrophic Epidermolysis Bullosa (DEB), and most mice die within 6 days after birth.
Application Area
Research on Epidermolysis bullosa (EB)
Validation Data