B6-hCOL7A1*c.6527dupC
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Strain Description
This strain is a disease model constructed by introducing a common recurrent mutation (c.6527dupC) of the COL7A1 gene in human diseases into the mouse Col7a1 humanized model (Catalog Number: C001428). The homozygous B6-hCOL7A1*c.6527dupC mice exhibit a disease phenotype similar to human Dystrophic Epidermolysis Bullosa (DEB), and most mice die within 6 days after birth.
Application Area
Research on Epidermolysis bullosa (EB)
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