The cadherin16 (CDH16) gene encodes a calcium-dependent membrane-associated glycoprotein. This protein is exclusively expressed in the kidneys, hence it is also known as kidney-specific calcium-binding protein (ksp-calmodulin). The Cdh16-iCre mouse was generated by inserting an optimized codon-modified Cre recombinase (iCre) gene expression cassette into the endogenous Cdh16 gene of mice, driving its specific expression. The iCre recombinase expression pattern is similar to the endogenous gene, and the mouse Cdh16 gene expression remains unaffected. When the Cdh16-iCre mice are crossed with mice containing loxP sites, the offspring's renal and genitourinary tract epithelial cells can undergo sequence recombination between loxP sites mediated by Cre recombinase.