B6-hTL1A (TNFSF15)
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Genotype
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Basic Information
Model Name
B6-hTL1A (TNFSF15)
Product ID
C001603
Gene Name
Background
C57BL/6JCya
Gene Alias
TL1; TL1A; VEGI; TNLG1B; VEGI192A
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
9
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Note: When using this mouse strain in a publication, please cite “B6-hTL1A (TNFSF15) mice (Catalog C001603) were purchased from Cyagen.”
Strain Description
The B6-hTL1A (TNFSF15) mouse is a humanized model constructed by replacing the mouse Tnfsf15 gene in situ with the human TNFSF15 gene using gene editing technology, in which the mouse Tnfsf15 endogenous extracellular domain (aa.61~253) will be replaced with the human TNFSF15 extracellular domain (aa.57~252). The homozygous B6-hTL1A (TNFSF15) mice are viable and fertile, and can be used for studies on T cell differentiation and survival, immune response regulation, and pathogenesis of autoimmune diseases, as well as for TL1A-targeted drug development.
Application Area
T cell differentiation and survival studies
Immune response regulation research
Pathogenesis of autoimmune diseases studies
TL1A-targeted drug screening, development and evaluation
Validation Data