B6-hIL6RA
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL6RA
Product ID
C001606
Gene Name
Background
C57BL/6NCya
Gene Alias
IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hIL6RA mice (Catalog C001606) were purchased from Cyagen.”
Strain Description
The B6-hIL6RA mouse is an Il6ra gene humanized model, in which the coding sequence (CDS) of the human IL6R gene is inserted into the endogenous Il6ra gene sequence of mice. This model can be used in researching autoimmune diseases, inflammation-related diseases, cancer, and infectious diseases. It is also useful for the development, screening, and evaluation of IL6RA-targeted drugs.
Application Area
Research on autoimmune diseases, inflammation-related diseases, cancer, and infectious diseases
Preclinical studies on the development, screening, and evaluation of IL6RA-targeted drugs
Validation Data