B6-hIL12B
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIL12B
Product ID
C001619
Gene Name
Background
C57BL/6NCya
Gene Alias
CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “B6-hIL12B mice (Catalog C001619) were purchased from Cyagen.”
Strain Description
B6-hIL12B mice are humanized models generated by gene editing technology, in which the entire base sequence of the mouse Il12b gene was replaced in situ with the corresponding sequence from the human IL12B gene. Homozygous B6-hIL12B mice are viable and fertile. This model can be used to study the pathological mechanisms and therapeutic methods of immune-related diseases and cancer, as well as the screening and development of IL12B-targeted drugs, and preclinical efficacy and safety evaluations.
Application Area
Screening, development, and preclinical efficacy evaluation of IL12B-targeted drugs
Study of pathological mechanisms and therapeutic methods for immune-related diseases and cancer
Validation Data