B6-hIGF1R
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIGF1R
Product ID
C001623
Gene Name
Background
C57BL/6NCya
Gene Alias
IGFR; CD221; IGFIR; JTK13
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
15
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Note: When using this mouse strain in a publication, please cite “B6-hIGF1R mice (Catalog C001623) were purchased from Cyagen.”
Strain Description
B6-hIGF1R mice are humanized models generated using gene editing technology by integrating the protein-coding sequence (CDS) encoding the extracellular domain of human IGF1R protein and the intracellular domain of mouse IGF1R protein into the mouse Igf1r gene locus, while retaining the endogenous gene sequence encoding the signal peptide of mouse IGF1R protein (aa.1-30). Homozygous B6-hIGF1R mice are viable and fertile, and can be used for studying the pathological mechanisms and treatments of growth retardation, diabetes, and cancer, as well as for screening, developing, and preclinical efficacy and safety evaluation of IGF1R-targeted drugs.
Application Area
Screening, development, and evaluation of IGF1R-targeted drugs
Study of the mechanisms and therapies for thyroid eye disease (TED)
Study of the pathological mechanisms and treatments for growth retardation, diabetes, and cancer
Validation Data