B6-hIL4RA
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL4RA
Product ID
C001629
Gene Name
Background
C57BL/6NCya
Gene Alias
CD124; IL4RA; IL-4RA
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
16
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Note: When using this mouse strain in a publication, please cite “B6-hIL4RA mice (Catalog C001629) were purchased from Cyagen.”
Strain Description
B6-hIL4RA mice are humanized models generated using gene editing technology by replacing the extracellular domain of the mouse Il4ra (aa.28~217) with the corresponding human IL4R extracellular domain (aa.28~216), while retaining the murine signal peptide (aa.1~25). Homozygous B6-hIL4RA mice are viable and fertile. This model is an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it is a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4Rα.
Application Area
Investigation of immune regulation and Th2 responses, allergic diseases, parasitic infections, and tumor immunology
Preclinical development, screening, and efficacy evaluation of IL-4Rα-targeted therapeutic agents
Studies on inflammation and autoimmune diseases
Validation Data