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B6-hFcRn (Extra)
Product ID:
C001701
Background:
C57BL/6NCya
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Strain Description
This model is a humanized FcRn mouse, in which the sequence encoding the extracellular domain of the endogenous protein in the mouse Fcgrt gene has been replaced by the corresponding sequence in the human FCGRT gene. B6-hFcRn (Extra) mice are therefore useful for in vivo studies of IgG, screening of IgG antibody drug candidates, and evaluating the pharmacology, efficacy, and pharmacokinetics of drugs. The homozygous mice are viable and fertile.
Application Area
Area
In vivo transport, maintenance, and metabolism studies of IgG
Area
Development and screening of IgG antibody drug candidates
Area
Pharmacology, efficacy, and pharmacokinetics of IgG antibody drugs
Area
Evaluation of Fc-based immunotherapy
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