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B6-hFcRn (Extra)
Product ID:
C001701
Background:
C57BL/6NCya
Documents:
Click here to download >
Product Type
Age
Genotype
Sex
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Price:
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Basic Information
Model Name
B6-hFcRn (Extra)
Product ID
C001701
Gene Name
FCGRT
Background
C57BL/6NCya
Gene Alias
FCRN; FcgammaRn; alpha-chain
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
2217
Phenotype
MGI:103017
Chromosome
19
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hFcRn (Extra) mice (Catalog C001701) were purchased from Cyagen.”
Strain Description
This model is a humanized FcRn mouse, in which the sequence encoding the extracellular domain of the endogenous protein in the mouse Fcgrt gene has been replaced by the corresponding sequence in the human FCGRT gene. B6-hFcRn (Extra) mice are therefore useful for in vivo studies of IgG, screening of IgG antibody drug candidates, and evaluating the pharmacology, efficacy, and pharmacokinetics of drugs. The homozygous mice are viable and fertile.
Application Area
Area
In vivo transport, maintenance, and metabolism studies of IgG
Area
Development and screening of IgG antibody drug candidates
Area
Pharmacology, efficacy, and pharmacokinetics of IgG antibody drugs
Area
Evaluation of Fc-based immunotherapy
Validation Data
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