BRG mice are models with the double knockout of Il2rg and Rag2 genes. This model presents more severe depletion of B cells, T cells, and NK cells as well as other severe combined immunodeficiency phenotypes than mice with knockout of either the Il2rg or Rag2 genes alone. The BRG-Cd47 KO mouse is a gene knockout model created using gene-editing techniques to knock out the coding sequence of the Cd47 gene in BRG mice. This model can be used for research in various fields of oncology and immunology.