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B6-hPCSK9/TG-hAPOC3
Product ID:
C001744
Background:
C57BL/6NCya
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Strain Description
B6-hPCSK9/TG-hAPOC3 mice are humanized models generated by crossing B6-hPCSK9 mice (Catalog No.: C001617) with TG-hAPOC3 mice (Catalog No.: C001588), enabling systemic expression of human PCSK9 and ApoC-Ⅲ proteins. This model is suitable for developing drugs targeting human APOC3/PCSK9, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), for treating hypertriglyceridemia and other metabolic disorders, as well as for research on neurodegenerative diseases, tumorigenesis, and autoimmune diseases.
Application Area
Area
Development of human APOC3/PCSK9-targeted drugs
Area
Research on metabolic diseases including hypertriglyceridemia, hypercholesterolemia, and atherosclerosis
Area
Research on neurodegenerative diseases, tumorigenesis, and autoimmune diseases
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