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Ctnnd2-tdTomato-loxP-Stop-loxP-DTR
Product ID:
C001751
Background:
C57BL/6JCya
Documents:
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Expressing Tissues/Cells:
Hippocampus, cerebral cortex, frontal lobe, cerebellum, central nervous system, and Ctnnd2-positive cells
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Strain Description
The TAA stop codon was replaced with the “P2A-tdTomato-IRES-loxP-6xSV40 pA loxP-DTR” cassette. Upstream of the DTR (diphtheria toxin receptor) gene lies a loxP-Stop-loxP cassette that blocks DTR transcription and expression. In the absence of Cre recombinase, the Ctnnd2 promoter drives tdTomato expression, labeling Ctnnd2-positive cells with red fluorescence. Upon Cre recombination, Cre-mediated deletion of the loxP-flanked stop (LSL) element enables DTR expression in Cre-positive cells. Intravenous administration of diphtheria toxin (DT) then selectively ablates these cells.
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