Gfi1-EGFP-CreERT2
Product ID:
C001753
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Hematopoietic stem cells, T cell progenitor cells, pancreas, thymus, inner ear hair cells, and Gfi1-positive cells
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Strain Description
The TGA stop codon was replaced with the P2A-EGFP-CreERT2 cassette. CreERT2 recombinase and enhanced green fluorescent protein (EGFP) are expressed under the regulatory control of Gfi1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in Gfi1-positive cells following Tamoxifen induction. In addition to studies of Cre recombinase-mediated gene recombination, this model can also be used for EGFP fluorescent protein tracing studies.
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