Lcn2-DTR-EGFP
Product ID:
C001757
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Osteoblasts, white adipose tissue, liver, astrocytes, kidney, and Lcn2-positive cells
Product Type
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Basic Information
Model Name
Lcn2-DTR-EGFP
Product ID
C001757
Gene Name
Background
C57BL/6JCya
Gene Alias
NRL; 24p3; Sip24
Classification
Reporter Mouse Lines
NCBI ID
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “Lcn2-DTR-EGFP mice (Catalog C001757) were purchased from Cyagen.”
Strain Description
The TGA stop codon was replaced with “P2A-DTR-EGFP” cassette. DTR (Diphtheria Toxin Receptor) and enhanced green fluorescent protein (EGFP) are expressed under the regulatory control of Lcn2 gene elements, without impacting the endogenous expression of the Lcn2 gene. Lcn2-positive cells display green fluorescence, injecting diphtheria toxin (DT) can selectively ablate these cells. This model enables EGFP fluorescence protein tracing studies.
Validation Data