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Lcn2-DTR-EGFP
Product ID:
C001757
Background:
C57BL/6JCya
Documents:
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Expressing Tissues/Cells:
Osteoblasts, white adipose tissue, liver, astrocytes, kidney, and Lcn2-positive cells
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Strain Description
The TGA stop codon was replaced with “P2A-DTR-EGFP” cassette. DTR (Diphtheria Toxin Receptor) and enhanced green fluorescent protein (EGFP) are expressed under the regulatory control of Lcn2 gene elements, without impacting the endogenous expression of the Lcn2 gene. Lcn2-positive cells display green fluorescence, injecting diphtheria toxin (DT) can selectively ablate these cells. This model enables EGFP fluorescence protein tracing studies.
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