BALB/c-hIL4
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
BALB/c-hIL4
Product ID
C001780
Gene Name
Background
BALB/cAnCya
Gene Alias
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “BALB/c-hIL4 mice (Catalog C001780) were purchased from Cyagen.”
Strain Description
The BALB/c-hIL4 mouse is a humanized model constructed via gene-editing technology, where the sequence of the murine endogenous Il4 gene is replaced with the counterpart of the human IL4 gene. This model serves as a valuable tool for researching allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Additionally, it provides a robust preclinical research platform for evaluating the efficacy and mechanisms of therapeutic drugs targeting the IL-4 pathway.
Application Area
Investigation of immune regulation and Th2 responses, allergic diseases, parasitic infections, and tumor immunology
Preclinical development, screening, and efficacy evaluation of IL4-targeted therapeutic agents
Studies on inflammation and autoimmune diseases
Validation Data